解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::In this report, an extremely rare case of pediatric thyrotropin-secreting pituitary macroadenoma (TSHoma) is described. An 8-year-old boy, complaining of unsteady gait, was suspected of endocrinopathy because of emaciation and muscle weakness of the legs. Endocrinological work-up established a diagnosis of hyperthyroi...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-010-0275-y
更新日期:2012-03-01 00:00:00
abstract::We report a 59-year-old acromegalic woman, who presented with generalized bone pain, weakness, fatigue and foamy urine, who was found to have multiple myeloma (MM); and a 60-year-old acromegalic woman with dizziness, vomiting and abdominal pain, high blood pressure and splenomegaly that was posteriorly diagnosed as ha...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-009-0176-0
更新日期:2011-12-01 00:00:00
abstract::We report on a 74-year-old male patient who presented with progressive neuroophthalmologic symptoms soon after the administration of a long-acting gonadotropin-releasing hormone agonist for treatment of a prostate cancer. Imaging revealed a destructively growing and extensively calcified sellar mass inconsistent with ...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-009-0199-6
更新日期:2011-12-01 00:00:00
abstract::Hyperprolactinemia has been associated with impaired metabolism, including insulin resistance. However, the metabolic effects of elevated prolactin (PRL) levels are not completely clarified. The aim of this study was to obtain more insights of metabolic consequences in hyperprolactinemia patients. Fourteen consecutive...
journal_title:Pituitary
pub_type: 临床试验,杂志文章
doi:10.1007/s11102-010-0277-9
更新日期:2011-09-01 00:00:00
abstract::Anemia and other hematological abnormalities are common in patients with Sheehan's syndrome. The response of these abnormalities to replacement of thyroxine and glucocorticoids is not clear. The aim of the present study was to document the profile of hematological abnormalities and response to treatment in patients wi...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-010-0255-2
更新日期:2011-03-01 00:00:00
abstract::Oral estrogens reduce GH-induced IGF-1 production and preliminary studies have shown that adjuvant estroprogestin (EP) therapy with octreotide LAR may control disease activity in some female patients who are partially responsive to octreotide LAR. Our aim was to verify if EP alone or in combination with octreotide LAR...
journal_title:Pituitary
pub_type: 临床试验,杂志文章
doi:10.1007/s11102-010-0236-5
更新日期:2010-12-01 00:00:00
abstract::Pituitary radiotherapy (RT) is an effective second-line treatment for paediatric Cushing's disease (CD). We report long-term efficacy and anterior pituitary function in a cohort of paediatric CD patients treated with RT. Between 1988 and 2008, from our cohort of 48 paediatric CD patients, eight paediatric CD patients ...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-010-0231-x
更新日期:2010-12-01 00:00:00
abstract::In this report we emphasize the opportunity of considering the uncommon causes of chronic GH-excess in the initial diagnostic process, such as GHRH hypersecretion, especially in the presence of ambiguous pituitary neuroimaging. This topic may have an important clinical significance in order to plan the most cost-effec...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-008-0146-y
更新日期:2010-09-01 00:00:00
abstract::GH and IGF-1 play an important role in the regulation of metabolism and body composition. In patients with uncontrolled acromegaly, cardiovascular morbidity and mortality are increased but are supposed to be normalised after biochemical control is achieved. We aimed at comparing body composition and the cardiovascular...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-010-0218-7
更新日期:2010-09-01 00:00:00
abstract::Arterial bleeding during transsphenoidal surgery for pituitary adenoma is known complication. This usually happens due to rupture of intracavernous carotid or delayed hemorrhage due to the carotico-cavernous fistula and/or pseudoaneurysm. There is also evidence that cavernous carotid aneurysms may occur with pituitary...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1007/s11102-009-0198-7
更新日期:2010-06-01 00:00:00
abstract::Inferior petrosal sinus sampling (IPSS) of ACTH with CRH stimulation helps distinguish pituitary ACTH-dependent Cushing's syndrome from the ectopic ACTH syndrome (EAS). The usefulness of the paradoxical response of other pituitary hormones including prolactin to CRH remains controversial. Data from 33 IPSS procedures ...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-009-0200-4
更新日期:2010-06-01 00:00:00
abstract::We report the case of a 60 year old male who complained of headache and blurry vision--that progressed to left ophthalmoplegia and ptosis--after receiving a dose of leuprolide for Prostate cancer therapy. Imaging showed a hemorrhagic sellar mass. The patient underwent transsphenoidal debulking, and the tissue obtained...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1007/s11102-009-0202-2
更新日期:2010-01-01 00:00:00
abstract::Leptin is a key mediator in the maintenance of neuroendocrine homeostasis. The aim of this study was to determine the changes in serum leptin, tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), nitric oxide (NO) levels in patients with hyperprolactinemia. The study consists of 16 consecutive patients with ...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-008-0140-4
更新日期:2009-01-01 00:00:00
abstract::Lymphoma involving the pituitary gland is very rare and usually results from metastatic spread of systemic lymphoma. We present a case of primary central nervous system (CNS) large B cell lymphoma that manifested as pituitary apoplexy. A 45-year-old woman presented with headache, and then rapidly developed a third ner...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-008-0084-8
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:Lymphocytic hypophysitis (LH) is a rare chronic inflammatory disorder characterized by lymphocytic infiltration of the pituitary gland commonly affecting women during pregnancy or post-partum period. The pathogenesis remains uncertain, however an autoimmune process is frequently implicated. There is limited d...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-008-0119-1
更新日期:2009-01-01 00:00:00
abstract::Published data on the effects of androgen deficiency and testosterone administration on body composition in men and women are reviewed. In experimental paradigms, androgen deprivation decreases lean body mass and increases fat mass in men, and physiologic replacement reverses these abnormalities. The anabolic effects ...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1007/s11102-008-0121-7
更新日期:2009-01-01 00:00:00
abstract::Aggressive pituitary adenomas are notoriously difficult to manage due to their size, invasiveness, speed of growth and high frequency of recurrence. Except for prolactinomas, surgery (usually transsphenoidal but sometimes transcranial) is the first-line option, but re-growth of aggressive tumors is almost inevitable a...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1007/s11102-008-0153-z
更新日期:2009-01-01 00:00:00
abstract::The simultaneous occurrence of a hypothalamic and sellar gangliocytoma with a pituitary prolactinoma is very rare. The explanation for such an association is not known. We describe the case of a woman who had a coexisting adjacent pituitary prolactinoma and gangliocytoma within the same sellar mass. The tumor cells of...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-007-0022-1
更新日期:2008-01-01 00:00:00
abstract::The molecular pathogenesis of prolactinomas has resisted elucidation; with the exception of a RAS mutation in a single aggressive prolactinoma, no mutational changes have been identified. In prolactinomas, a further obstacle has been the paucity of surgical specimens suitable for molecular analysis since prolactionoma...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-007-0082-2
更新日期:2008-01-01 00:00:00
abstract::Ideal surgical treatment of craniopharyngiomas remains a major challenge for neurosurgeons. Craniopharyngiomas grow in the deep-seated hypothalamic area that is paramount for vegetative, emotional and endocrine function, and for maintaining worthwhile life. The benign histological nature of craniopharyngiomas belies t...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1007/s11102-008-0137-z
更新日期:2008-01-01 00:00:00
abstract::Medications commonly cause hyperprolactinemia and their use must be differentiated from pathologic causes. The most common medications to cause hyperprolactinemia are the antipsychotic agents, although some of the newer atypical antipsychotics do not do so. Other medications causing hyperprolactinemia include antidepr...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1007/s11102-008-0106-6
更新日期:2008-01-01 00:00:00
abstract::An unusual case of tubercular granulomatous hypophysitis is reported. A sellar mass diagnosed as pituitary adenoma in MRI, showed non-caseating granulomas, glandular destruction and fibrosis in histology. Stain for acid-fast bacilli (AFB) were negative and the case was misdiagnosed as Idiopathic Granulomatous hypophys...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-007-0068-0
更新日期:2008-01-01 00:00:00
abstract::Wegener's granulomatosis (WG) is an anti-neutrophil cytoplasmic antibody (ANCA)-associated systemic vasculitis of small and medium-sized vessels. Pituitary involvement in WG is rare with only 22 previous case reports in the English medical literature between 1966 and 2006. Herein we report another patient with WG-rela...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1007/s11102-007-0021-2
更新日期:2008-01-01 00:00:00
abstract::It is estimated that up to one in five individuals develops pituitary gland tumors, despite the common occurrence of these tumors, the pathogenetic mechanisms underlying their development mainly remain unknown. We studied the gene expression in null cell adenomas compared with normal pituitary by expressed sequence ta...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-007-0008-z
更新日期:2007-01-01 00:00:00
abstract::The diagnoses of acromegaly and dwarfism require biochemical confirmation of abnormal GH and IGF-1 concentrations. The same parameters are used for therapeutic decisions, i.e. initiation or termination of particular treatments. Therefore, reliable and epidemiologically and statistically proven criteria of normalcy for...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1007/s11102-007-0029-7
更新日期:2007-01-01 00:00:00
abstract::The diagnosis of disorders of growth hormone (GH) is dependent upon accurate measurement of insulin-like growth factor-I (IGF-I) concentrations since serum IGF-I assays have been found to be useful as a screening tests for the presence of growth hormone deficiency (GHD) in children and in both children and adults they...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1007/s11102-007-0032-z
更新日期:2007-01-01 00:00:00
abstract::Glucocorticoids are important immunosuppressive hormones; these steroids also inhibit somatic growth by decreased growth hormone (GH) secretion and induced protein catabolism. The ability of ghrelin, the endogenous ligand for the GHS-1a receptor, to increase body weight is attributed to a combination of enhanced food ...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-007-0054-6
更新日期:2007-01-01 00:00:00
abstract::A young female patient presented as an acute medical emergency with hypoglycaemia. Investigations revealed panhypopituitarism and an inflammatory pituitary mass. An antibody screen was negative for anti-neutrophil cytoplasmic antibodies with cytoplasmic distribution (cANCA). Pituitary histology showed lymphocytic infi...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-007-0016-z
更新日期:2007-01-01 00:00:00
abstract:CONTEXT:Octreotide causes significant tumour shrinkage in patients with acromegaly but the exact mechanism of action is unclear in vivo. OBJECTIVE:To determine the mechanism of action of octreotide in vivo using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). DESIGN:Five patients with acromegaly were ...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-007-0044-8
更新日期:2007-01-01 00:00:00
abstract::Adipsic diabetes insipidus (ADI) is a rare condition in which thirst, an essential clinical feature for the prevention of hypernatraemic dehydration, is absent. We report the first case of adipsic diabetes insipidus to occur following surgery for a pituitary macroprolactinoma, with loss of both osmoregulated and baror...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-006-8280-x
更新日期:2006-01-01 00:00:00
abstract::We report the results of long-term (6-year) treatment of Nelson's syndrome with the long-acting dopamine agonist, cabergoline, in a 55-year-old woman. The disease presented 26 years after bilateral adrenalectomy and radiation treatment for Cushing's disease, followed by glucocorticoid and mineralocorticoid replacement...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-006-9290-4
更新日期:2006-01-01 00:00:00
abstract::Cushing's disease, i.e., pituitary ACTH-secreting adenoma causing excess glucocorticoid secretion, is a rare disease with significant mortality and morbidity. Timely diagnosis and appropriate treatment can alter the course of the disease and are therefore mandatory. First step of the diagnostic work-up is the endogeno...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1007/s11102-006-0407-6
更新日期:2006-01-01 00:00:00
abstract::MAP-2, a well characterized member of the microtubule associated protein (MAP) family, binds to and stabilizes microtubules and is involved in cell proliferation as well as neuronal differentiation. The aim of the present work was to study MAP-2 expression in human adenohypophyses and pituitary adenomas. To our knowle...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-005-1523-4
更新日期:2005-01-01 00:00:00
abstract::The management of invasive giant prolactinomas (IGP) has been an area of some controversy. The relative roles of transsphenoidal surgery, craniotomy, radiation therapy and dopamine agonist based medical therapy are gradually becoming clarified. We report the results of management of 30 patients with IGP. Surgery was t...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-005-5087-0
更新日期:2005-01-01 00:00:00
abstract::Adequate ADH secretion, adrenal and thyroid functions are vital during the acute and post-acute phases of TBI. Deficiencies of these functions as a result of TBI are increasingly recognized. During the acute phase of TBI the incidence of severe DI is 2.9%; the incidence of less severe forms of DI is 21.6-26%. The deve...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1007/s11102-006-6049-x
更新日期:2005-01-01 00:00:00
abstract::Growth hormone releasing hormone (GHRH) signals via G protein-coupled receptors (GHRH-R) to enhance intracellular Galphas/adenylyl cyclase/cAMP signaling, which in turn has positive effects on GH synthesis and release, as well as proliferation of the GH-producing cells of the anterior pituitary gland. Some GH-producin...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-005-5245-4
更新日期:2005-01-01 00:00:00
abstract::Clinically inapparent adrenal masses, or adrenal incidentalomas, are discovered inadvertently in the course of workup or treatment of unrelated disorders. Cortical adenoma is the most frequent type of adrenal incidentaloma accounting for approximately 50% of cases in surgical series and even greater shares in medical ...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1007/s11102-005-4024-6
更新日期:2004-01-01 00:00:00
abstract::Dopamine agonists have been shown to reduce growth hormone secretion in some patients with acromegaly, but their effect on adenoma size has not been well appreciated. We describe a 69 year-old woman with acromegaly caused by a somatotroph macroadenoma who received primary treatment with the dopamine agonist cabergolin...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-005-5353-1
更新日期:2004-01-01 00:00:00
abstract::The role of pituitary radiotherapy (RT) in the management of clinically non-functioning pituitary tumors (NFTs) remains controversial. Observational studies suggest that RT is effective in preventing the regrowth of NFT remnants following initial surgical debulking. However, not all tumor remnants will regrow in the a...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1023/b:pitu.0000004801.95086.e2
更新日期:2003-09-01 00:00:00
abstract::Resistance to dopamine agonists can be defined with respect to failure to normalize PRL levels and failure to decrease tumor size by > or = 50%. Using these definitions, failure to normalize PRL levels is seen in 24% of those treated with bromocriptine, 13% of those treated with pergolide and 11% of those treated with...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1023/a:1026225625897
更新日期:2003-01-01 00:00:00